Netcare 911 responded to a collision on the M41 East Bound in Umhlanga Ridge, Durban.
Reports allege that a truck driver lost control travelling down the road when he ploughed through morning traffic.
On scene with Netcare 911 was Emer-G-Med paramedics, SAPS, Durban Metropolitan SAR, Ethekwini Fire and Rescue.
Medics assessed the scene and found twenty two patients, who had sustained injuries ranging from serious to minor injuries.
Many patients had been transported privately prior to the arrival of emergency services.
A Netcare 911 helicopter ambulance has been activated to airlift patients from the scene.
The scene is still active and an update is pending.