Mamelodi Sundowns and AmaZulu FC will miss key players ahead of their respective DStv Premiership clashes this coming weekend.
Downs have been in incredible form lately, winning 13 matches in a row to set a new Premier Soccer League record.
However, this weekend they will have to do without a key duo when they take on in-form Sekhukhune United, who have won their last four games in a row.
Themba Zwane, who has been one of the standout players in the team, will miss the clash with Babina Noko, while Grant Kekana is also suspended.
Mshishi received his fourth yellow card against TS Galaxy, having previously been cautioned against Kaizer Chiefs, and twice against Orlando Pirates in the MTN8 semi-final first- and second leg.
Kekana also will miss the clash after receiving his fourth yellow card against Galaxy, previously receiving three yellow cards against AmaZulu FC, Pirates in the MTN8 semi-final first leg and one in the league match against the Buccaneers.
Meanwhile, Usuthu will have to battle in KZN derby at second-placed Richards Bay without their midfield maestro George Maluleka after receiving his last yellow card against Marumo Gallants and previously being cautioned against Gallants, Kaizer Chiefs and SuperSport United.
The other players who are suspended this weekend are Divine Lunga (Golden Arrows), Justice Chabalala (Chippa United), Mbhazima Rikhotso (Royal AM) and Swallows duo Gregory Damons and Mosa Nyatama.